Meningioma 1 (MN1)

MN1 is a transcription coregulator which enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300. MN1 also acts as a coactivator of the vitamin D receptor.

Using a balanced translocation t(4;22) found in a meningioma, Lekanne Deprez et al. (1995) isolated a gene, which they designated MN1, that was disrupted by the translocation. The cDNA encoded a protein of 1,319 amino acids when the first methionine in the open reading frame was used. The MN1 cDNA contained 2 sets of CAG repeats, one of which coded for a string of 28 glutamines.Lekanne Deprez et al. (1995) determined that the MN1 gene spans about 70 kb and consists of at least 2 large exons of approximately 4.7 kb and 2.8 kb.