Metallo Beta Lactamase Domain Containing Protein 1 (MbLAC1)

MbLAC1 Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.The metallo-beta-lactamase protein fold is a protein domain contained in class B beta-lactamases and a number of other proteins. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake.

Except for the competence protein these proteins bind two zinc ions per molecule as cofactor. Metallo-beta-lactamases are important enzymes because they are involved in the breakdown of antibiotics by antibiotic-resistant bacteria.