Metallophosphoesterase 1 (MPPE1)

MPPE1 gene contains 14 exons and spans about 27 kb. They detected 4 alternatively spliced forms: the most abundant form contains exons 1, 2, 5-12, and 14, and another form consists of exons 1, 2, and 5-14; the 2 rare forms correspond to these 2, but lack the sequences for exon 10.

The most abundant form encodes a deduced 396-amino acid protein with a signal sequence, a metallophosphoesterase domain, and a putative transmembrane domain. One of the alternative forms encodes a truncated 340-amino acid protein. Northern blot analysis detected a single 2.2-kb MPPE1 mRNA in brain, but not in any other tissues tested. The 3 alternative forms were detected in brain by RT-PCR only.