Metallophosphoesterase Domain Containing Protein 1 (MPPED1)

MPPED1 was isolated from adult brain library and shares 79% identity with 239FB isolated from fetal brain.The deduced amino acid sequence of 239AB was 302 amino acids long and contained 8 additional amino acids at its N terminus compared to 239FB. Northern blot analysis detected a 4.4-kb transcript in all adult human tissues analyzed that was most prominent in pancreas, liver, skeletal muscle, heart, and testis. An intensely hybridizing 3.6-kb message was detected only in brain, and was the most abundant transcript in this tissue. Both genes are highly conserved from C. elegans to birds and mammals. the 239FB and 239AB genes belong to an ancient family of genes. Phylogenetic analysis suggested that 239FB and 239AB have origins dating back to a time before the emergence of modern animals.