Metastasis Suppressor 1 (MTSS1)

MIM and GLI1 acted synergistically to recapitulate SHH-mediated epidermal proliferation and invasion in regenerated human skin. Coimmunoprecipitation and protein-binding studies indicated that MIM is part of a GLI/suppressor of fused (SUFU) complex. SUFU appeared to associate with MIM in the absence of GLI. Mutation analysis indicated that an N-terminal domain of MIM distinct from those used for monomeric actin binding was required for both complex association and transcriptional potentiation.MTSS1 contains a proline-rich region and an actin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2). It has a predicted molecular mass of 38 kD. MTSS1 transcript in human spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.