Methyltransferase Like Protein 9 (METTL9)

The deduced proteins, designated DREV (DORA reverse strand) proteins, show weak homology to ribosomal RNA adenine dimethylases and contain conserved consensus sequences for the recognition of nucleotide methyl groups and possibly for methyl group transfer. Northern blot analysis of mouse tissues detected ubiquitous and variable Drev expression.

DREV gene contains 5 exons. The 5-prime UTR has a high GC content. Intron 4 of the DREV gene contains the entire IGSF6 gene on the complementary strand, and there is a retrotransposon-like sequence between the 3-prime end of the IGSF6 gene and exon 4 of the DREV gene.