Methyltransferase Like Protein 1 (METTL1)

METTL1 is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.

The predominant transcript encodes a deduced 276-amino acid human METTL1 protein that shows high sequence similarity to putative proteins from mouse, Drosophila, A. thaliana, C. elegans, and yeast. Computer analyses of these proteins revealed 2 highly conserved amino acid motifs, one of which is an S-adenosylmethionine-binding domain typical of methyltransferases; the other motif has no known function.