Methyltransferase Like Protein 13 (METTL13)

METTL13 is putatively involved with methyltransferase activity and is 16 kb in length. Interestingly, DNA methyltransferases have been shown to play a role in estrogen receptor-induced gene transcription. Six of the available SNPs passing quality control in METTL13 were at least nominally significant. The genotyped SNPs captured 88% of the common variation in this gene.
HMCN1 and METTL13 have not been previously examined for association with peripartum mood syndromes. Specifically, the genes HMCN1 and METTL13 may contain polymorphisms that confer susceptibility to postpartum mood symptoms. As both the linkage and association results presented here are novel, future studies replicating these findings are warranted.