Mitochondrial Ribosomal Protein L12 (MRPL12)

Marty and Fort (1996) cloned a cDNA from a HeLa cell library that encodes a protein localized predominantly to the mitochondria and is homologous to bacterial and chloroplast ribosomal L12 proteins. They designated it 'mitochondrial ribosomal protein L12,' or MRPL12. The predicted 198-amino acid protein has a 49-amino acid N-terminal mitochondrial targeting sequence.

Marty et al. (1997) found a single 1.2-kb mRNA transcribed primarily in colon and skeletal muscle, with lower levels in other tissues. Marty et al. (1997) mapped the MRPL12 gene to 17q25-qter by fluorescence in situ hybridization.