Mitochondrial Ribosomal Protein L19 (MRPL19)

MRPL19 encodes a 39S subunit protein. Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRPL19 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome. By sequencing clones obtained from a size-fractionated human immature myeloid cell line cDNA library, Nagase et al. (1995) cloned MRPL19, which they designated KIAA0104. Northern blot analysis detected expression in all tissues and cell lines examined, with highest levels in HeLa cells, heart, liver, skeletal muscle, kidney, and pancreas.By searching databases using bovine Mrpl19 as query, followed by PCR of human genomic DNA, Kenmochi et al. (2001) cloned MRPL19.