Mitochondrial Ribosomal Protein L28 (MRPL28)

Mitochondria have their own translation system for production of 13 inner membrane proteins essential for oxidative phosphorylation. MRPL28 is a component of the large subunit of the mitochondrial ribosome that is encoded by the nuclear genome.

TILs recognize and lyse melanoma cells in an MHC class I- or class II-restricted manner. The antigens may be encoded by nonmutated genes in which the level of expression is increased in melanoma. The cDNA encodes a deduced 128-amino acid protein, MAAT1, termed p15 by the authors. The lack of a signal peptide, N-linked glycosylation sites, and hydrophobic domains suggests that MAAT1 is a cytoplasmic or nuclear protein.