Mitochondrial Ribosomal Protein S17 (MRPS17)

Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRPS17 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome.

The deduced 130-amino acid MRPS17 protein has a calculated molecular mass of 14.5 kD. Removal of a predicted 20-amino acid N-terminal mitochondrial localization signal results in a mature 12.4-kD protein. MRPS17 orthologs in mouse, Drosophila, C. elegans, yeast, and E. coli. Highest conservation is in the N-terminal and central regions of MRPS17 orthologs. Mouse and human MRPS17 share 84.2% amino acid identity.