Mitochondrial Ribosomal Protein S28 (MRPS28)

Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRPS28 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome.

MRPS28 protein contains 188 amino acids. MRPS28 protein, contains 187 amino acids and has a calculated molecular mass of 20.8 kD. Removal of a predicted 28-amino acid N-terminal mitochondrial localization signal results in a mature 17.6-kD protein. O'Brien et al. (2000) and Koc et al. (2001) identified MRPS28 orthologs in mouse, rat, Drosophila, and C. elegans, but not in yeast or E. coli. Koc et al. (2001) reported that mouse and human MRPS28 share 72.5% amino acid identity.