Mitogen Activated Protein Kinase 15 (MAPK15)

Mitogen-activated protein kinase 15 is an enzyme encoded by the MAPK15 gene.Mitogen-activated protein (MAP) kinases (EC 2.7.11.24) are serine/threonine-specific protein kinases that respond to extracellular stimuli (mitogens, osmotic stress, heat shock and proinflammatory cytokines) and regulate various cellular activities, such as gene expression, mitosis, differentiation, proliferation, and cell survival/apoptosis. Each one consists of three enzymes, MAP kinase, MAP kinase kinase (MKK, MEKK, or MAP2K) and MAP kinase kinase kinase (MKKK or MAP3K) that are activated in series. A MAP3K that is activated by extracellular stimuli phosphorylates a MAP2K on its serine and threonine residues, and the this MAP2K activates a MAP kinase through phosphorylation on its serine and tyrosine residues (Tyr-185 and Thr-183 of ERK2).