Mitogen Activated Protein Kinase 8 Interacting Protein 2 (MAPK8IP2)

MAPK8IP2 is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. The deduced 824-amino acid protein contains 2 N-terminal acidic regions, a JNK binding domain, 2 central proline-rich regions, a third acidic region, an SRC homology-3 domain, and a phosphotyrosine-binding domain. Northern blot analysis revealed expression of JIP2 in adult and fetal brain, and mRNA dot blot analysis detected low expression in uterus, prostate, colon, testis, ovary, pancreas, adrenal gland, thyroid gland, and salivary gland.