Mitogen Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3)

MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Human SYD1 is 69% similar to mouse Syd2 and 55% similar to Drosophila syd. The predicted SYD proteins have a transmembrane region flanked by an N-terminal domain containing 2 coiled-coil regions and a C-terminal domain containing a conserved hydrophobic core.