Multiple C2 And Transmembrane Domain Containing Protein 2 (MCTP2)

The MCTP2 gene is involved in intercellular signal transduction and synapse function. MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE).

The invertebrate organisms Caenorhabditis elegans and Drosophila melanogaster express a single MCTP gene, whereas vertebrates express two MCTP genes (MCTP1 and MCTP2) whose primary transcripts are extensively alternatively spliced. Most of the MCTP sequences, in particular the C2 domains, are highly conserved. All MCTP C2 domains except for the second C2 domain of MCTP2 include a perfect Ca2+/phospholipid-binding consensus sequence. C2 domains are anchored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but not phospholipid-binding modules.