Multiple PDZ Domain Protein (MPDZ)

The PDZ domain is a protein motif that mediates protein-protein interactions. It has been shown that the PDZ domains of some PDZ-containing proteins interact with the C-terminal tail sequences of specific ion channel subunits and G protein-coupled receptors.

The deduced 2,054-amino acid rat protein, which the authors named Mupp1 for 'multi-PDZ domain protein-1', has 13 PDZ domains, each containing the structural characteristics of a prototypic PDZ motif, but lacks a catalytic domain. The rat Mupp1 protein has high sequence similarity with human INADL. Some tissues also contained a 4.0- or 5.0-kb transcript, which the authors speculated may be alternative transcripts encoding smaller yet still functional variants of MUPP1.