Cholinergic Receptor, Muscarinic 3 (CHRM3)

The , also known as the cholinergic receptor, muscarinic 3, is a muscarinic acetylcholine receptor.

The M₃ muscarinic receptors are located at many places in the body, e.g. smooth muscles, endocrine, in exocrine glands, as well as in the lungs. They are also found in the CNS, where it induces emesis They generally cause smooth muscle contraction and increased glandular secretions.Like the M₁ muscarinic receptor, M₃ receptors are G proteins of class G_q, which upregulate phospholipase C and therefore inositol trisphosphate and intracellular calcium as a signalling pathway. The calcium function in vertebrates also involves activation of protein kinase C and its effects.