MutS Homolog 6 (MSH6)
GTBP; HNPCC5; HSAP; GTMBP; p160; G/T mismatch-binding protein; MutS-alpha 160 kDa subunit; DNA mismatch repair protein Msh6
MSH6 encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs.
The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant MutS Homolog 6 (MSH6) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to MutS Homolog 6 (MSH6) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to MutS Homolog 6 (MSH6) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for MutS Homolog 6 (MSH6) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for MutS Homolog 6 (MSH6) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant MutS Homolog 6 (MSH6) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to MutS Homolog 6 (MSH6) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to MutS Homolog 6 (MSH6) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for MutS Homolog 6 (MSH6) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for MutS Homolog 6 (MSH6) ELISA Kit Customized Service Offer