Myelin Expression Factor 2 (MYEF2)

VEGFis a key regulator of physiological and pathologic angiogenesis. Although much is known about the major upstream signaling pathways of VEGF in endothelial cells, less is known about key transcription factors involved in VEGF action. The transcription factor myocyte enhancer factor (MEF)-2C is thought to play an important role in vasculogenesis and angiogenesis during vascular development. VEGF as a key regulator of MEF2C and suggest that MEF2 may be an important mediator of VEGF in endothelial cells. The amino terminus of HDAC4 can associate with the DNA-bound MEF2 in vitro, suggesting that it does not repress MEF2 simply by disrupting the ability of MEF2 to bind DNA.In vivo, MEF2 induces nuclear translocation of both the full-length HDAC4 and HDAC4, whereas the nuclear HDAC4 as well as HDAC4 in turn specifically sequesters MEF2 to distinct nuclear bodies.