Myeloid Leukemia Factor 2 (MLF2)

Yoneda-Kato et al. (1996) showed that a t(3;5)(q25.1;q34) chromosomal translocation associated with myelodysplastic syndrome and acute myeloid leukemia (AML) resulted from an in-frame fusion between the 5-prime coding region of the nucleophosmin gene (NPM) on chromosome 5 and a gene on chromosome 3, designated MLF1 (myeloid leukemia factor-1). Kuefer et al. (1996) described a cDNA whose predicted 248-amino acid protein sequence is approximately 40% identical to myeloid leukemia factor 1. Expression of MLF2 was ubiquitous. Kuefer et al. (1996) mapped the gene by fluorescence in situ hybridization to 12p13, a region associated with translocations in acute leukemias of lymphoid and myeloid origin. However, they found no alterations in the structure of the MLF2 locus in patients shown to have 12p translocations.