Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4)

AF6 is a Ras target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL in leukemias caused by t(6;11) translocations.

The gene, designated AF6 by them, was found to be expressed in a variety of cell types and to encode a protein of 1,612 amino acids. The protein contains short stretches rich in proline, charged amino acids, serines, or glutamines. In addition, the AF6 protein contains the GLGF motif shared with several proteins of vertebrates and invertebrates thought to be involved in signal transduction at special cell-cell junctions.Mutation analysis indicated that the GTP-Ras-interacting domain was between amino acids 36 and 206 of bovine Af6.