Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 6 (MLLT6)

Leukemia associated with 11q23 abnormalities tend to show expression of both lymphoid and myeloid markers (hence, 'mixed-lineage leukemia'), massive cell burden, and poor prognosis.The AF17 gene encodes a protein of 1,093 amino acids, containing a leucine-zipper dimerization motif located 3-prime of the fusion point and a cysteine-rich domain at the N terminus. The latter can be arranged in 3 zinc fingers and shows homology to a domain within the protein Br140. AF17 was found to contain stretches of amino acids previously associated with domains involved in transcriptional repression or activation.partner polypeptide, such as that encoded by AF17, plays an accessory role either by repressing activity of the truncated ALL1 protein or by blocking the function of the normal protein presumably present in leukemic cells.