Myoneurin (MYNN)

A novel class of structurally related zinc finger proteins, characterized by a classic C2H2 zinc finger motif and a BTB/POZ protein-protein interaction domain, has been implicated in the control of a wide range of developmental events in Drosophila and mammals.

The MYNN cDNA encodes a deduced 610-amino acid protein that shares 95% sequence identity with the mouse protein. Between the BTB/POZ domain in the N terminus and 8 tandemly repeated zinc finger motifs of the Kruppel type in the C terminus, myoneurin has 2 potential nuclear localization signals. Two less abundant transcripts of 3.3 and over 5.0 kb were also identified in muscle and appeared to be underexpressed in testis and overexpressed in thymus, respectively.