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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)
CMH8; MLC1V; VLC1; MLC1SB
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Adenoviral gene transfer of p35 in vivo prevented caspase-3 activation and MYL3 cleavage, with positive impact on contractility. These data suggested that direct cleavage of the myosin light chain by activated caspase-3 may contribute to depression of myocyte function by altering crossbridge interaction between myosin and actin molecules. Therefore, activation of apoptotic pathways in the heart may lead to contractile dysfunction before cell death.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPD425Mu01 Recombinant Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
Antibodies PAD425Mu01 Polyclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
MAD425Mu21 Monoclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
Assay Kits SED425Mu ELISA Kit for Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
SCD425Mu CLIA Kit for Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPD425Ra01 Recombinant Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
Antibodies PAD425Ra01 Polyclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
MAD425Ra21 Monoclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
Assay Kits SED425Ra ELISA Kit for Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize
SCD425Ra CLIA Kit for Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Customize