Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)

CMH8; MLC1V; VLC1; MLC1SB; Cardiac myosin light chain 1; Ventricular/slow twitch myosin alkali light chain
Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Adenoviral gene transfer of p35 in vivo prevented caspase-3 activation and MYL3 cleavage, with positive impact on contractility. These data suggested that direct cleavage of the myosin light chain by activated caspase-3 may contribute to depression of myocyte function by altering crossbridge interaction between myosin and actin molecules. Therefore, activation of apoptotic pathways in the heart may lead to contractile dysfunction before cell death.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPD425Ra01Recombinant Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)Customize
  • AntibodyPAD425Ra01Polyclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)Customize
  • AntibodyMAD425Ra21Monoclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)Customize
  • Assay KitSED425RaELISA Kit for Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)Customize
  • Assay KitSCD425RaCLIA Kit for Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)Customize
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