Myosin Regulatory Light Chain Interacting Protein (MYLIP)

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation. The expression of IDOL is induced by the sterol-ativated liver X receptor.

MYLIP belongs to the ezrin (VIL2)-radixin (RDX)-moesin (MSN) (ERM) family of cytoskeletal effector proteins that link actin to membrane-bound proteins at the cell surface (Olsson et al., 1999).

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.