Myosin VI (MYO6)

Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies, and nematodes. Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.the sequence of the mouse Myo6 gene is 87% identical to that of the pig.

The mouse cDNA predicted a protein of 1,266 amino acids with a relative molecular mass of 142 kD. In the pig, rat, and mouse, myosin VI is widely expressed. In the mouse, within the cochlea of the inner ear, myosin VI is expressed specifically within the sensory hair cells.Expression of MYO6 in human fetal cochlea demonstrated the importance of myosin VI in the mammalian inner ear and supported its potential role in human inner ear pathology.