N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3)

NECAB3 interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation.

The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. The deduced 273-amino acid human protein contains a leucine zipper-like motif and shares 75.5% homology to its mouse ortholog.