NADH Dehydrogenase Ubiquinone 1 Beta Subcomplex 11 (NDUFb11)

NDUFB11 is a component of mitochondrial complex I. Complex I catalyzes the first step in the electron transport chain, the transfer of 2 electrons from NADH to ubiquinone, coupled to the translocation of 4 protons across the membrane. The deduced 153-amino acid protein has a calculated molecular mass of 17.3 kD and contains a typical PEST region found in rapidly degraded proteins. The 3-prime untranslated region contains an atypical polyadenylation signal (ATTAAA). The p17.3 protein shares 81% identity with the mouse Np15.6 protein. Northern blot analysis revealed a 0.6-kb transcript that was expressed, in decreasing order of abundance, in prostate, pancreas, colon, heart, skeletal muscle, kidney, thymus, spleen, small intestine, brain, liver, testis, peripheral blood leukocytes, ovary, placenta, and lung.