NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 6 (NDUFa6)

NADH Dehydrogenase is the first enzyme of the mitochondrial electron transport chain. There are three energy-transducing enzymes in the electron transport chain - NADH dehydrogenase (Complex I), Coenzyme Q – cytochrome c reductase (Complex III), and cytochrome c oxidase (Complex IV).

Dunbar et al. (1997) mapped the NDUFA6 gene to 21q22 by fluorescence in situ hybridization (FISH). However, by intron-based radiation hybrid mapping, Emahazion and Brookes (1998) assigned the NDUFA6 gene to 22q13.1. They stated that subsequent mapping studies with subfragments of the FISH-mapped recombinants of Dunbar et al. (1997) suggested chimerism and confirmed that the earlier FISH data were flawed.