NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 7 (NDUFa7)

Loeffen et al. (1998) isolated human cDNAs encoding NDUFA7 and 7 other complex I subunits. The predicted 113-amino acid human protein is 89% identical to B14.5A, the bovine homolog. Hydropathy analysis revealed that NDUFA7 and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. See NDUFA10. By intron-based radiation hybrid mapping, Emahazion and Brookes (1998) assigned the NDUFA7 gene to 19p13.2. Although Dunbar et al. (1997) had mapped the NDUFA7 gene to 20p13 by fluorescence in situ hybridization (FISH), Emahazion and Brookes (1998) stated that subsequent mapping studies with subfragments of the FISH-mapped recombinants of Dunbar et al. (1997) suggested chimerism and confirmed that the earlier FISH data were flawed.