NADH Dehydrogenase Ubiquinone 1 Beta Subcomplex 2 (NDUFb2)

NDUFb2 is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transferring electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I.The predicted 105-amino acid human protein is 84% identical to Aggg, its bovine homolog. Hydropathy analysis revealed that NDUFB2 and 4 other subunits had an overall hydrophilic pattern, even though they were found within the hydrophobic protein fraction of complex I.