NADH Dehydrogenase Ubiquinone 1 Beta Subcomplex 3 (NDUFb3)

The multisubunit NADH:ubiquinone oxidoreductase (complex I) is the first enzyme complex in the electron transport chain of mitochondria.

Ton et al. (1997) isolated human heart cDNAs encoding CI-B12 (NDUFB3) and 4 other complex I subunits.

Jensen et al. (2001) determined that the NDUFB3 gene contains 3 exons and spans 13.9 kb of genomic DNA.

By radiation hybrid analysis, Jensen et al. (2001) mapped the NDUFB3 gene to chromosome 2q31.3. They also mapped 4 NDUFB3 pseudogenes. One of the pseudogenes, NDUFB3P4, is positioned in intron 2 of the WARS gene in the opposite direction.