NADH Dehydrogenase Ubiquinone 1 Beta Subcomplex 6 (NDUFb6)

NDUFb6 is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

The B17 cDNA encodes a protein of 128 amino acids with a calculated relative mass of 15.5 kD. There was 82.7% and 78.1% homology, respectively, at the cDNA and amino acid levels with the bovine counterpart.