NADH Dehydrogenase Ubiquinone Fe-S Protein 5 (NDUFS5)

The multisubunit NADH:ubiquinone oxidoreductase (complex I) is the first enzyme complex in the electron transport chain of mitochondria. The iron-sulfur protein (IP) fraction is made up of 7 subunits.

By a combination of EST database searching and RT-PCR, Loeffen et al. (1999) isolated cDNAs encoding the human homolog of the bovine 15-kD IP subunit. The predicted 106-amino acid human NDUFS5 protein shares 75% homology with the bovine protein. Northern dot blot analysis revealed that NDUFS5 was expressed in all human tissues tested. Mao et al. (1998) identified an NDUFS5 cDNA, HD-CI-15, among a collection of cDNAs expressed in hematopoietic stem/progenitor cells.