N-myc Downstream Regulated Gene 3 (NDRG3)

This confirmed the existence of a human NDRG3 gene, homologous to mouse Ndr3. They found that the NDRG3 gene was represented by 86 ESTs and a genomic clone from chromosome 20q11.21-q11.23. This provisional chromosomal localization was confirmed by electronic PCR. In the same genomic clone, 4 STSs were identified that had been independently localized to chromosome 20 by means of radiation hybrid mapping.

The 3 known human NDRG proteins show considerable homology, with 54% amino acid sequence identity between NDRG1 and NDRG2, 67% between NDRG1 and NDRG3, and 58% between NDRG2 and NDRG3.