NLR Family, Pyrin Domain Containing Protein 10 (NLRP10)

NLRP10 belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.

The predicted 655-amino acid protein contains an N-terminal PYD and C-terminal nucleotide-binding oligomerization domain (NOD), but no LRR. It shares approximately 55% amino acid identity with rat and mouse Nalp10. NALP10 expression was also detected in various cell lines, including those of hemopoietic lineage.