NOP2/Sun Domain Family, Member 4 (NSUN4)

NSUN4, Belongs to the methyltransferase superfamily. RsmB/NOP family. May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

One variant lacks exon 3, resulting in a 35-amino acid deletion, and the other 2 variants encode smaller proteins lacking the SUN domain. RT-PCR detected predominant expression of full-length MISU and lower expression of the MISU variant lacking exon 3 in all human cell lines examined. Northern blot analysis detected ubiquitous expression of Misu in mouse tissues. MISU was distributed throughout the nucleus during S phase, when the number and size of nucleoli increase. In G2 phase, some MISU was detected in cytoplasmic vesicles, and MISU localized to the spindle during mitosis.