NSFL1 Cofactor (NSFL1C)

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.

Zhang et al. (2000) screened CD34-positive hemopoietic stem/progenitor cells for novel cDNAs and obtained a human homolog of p47. The deduced human p47 protein has 370 amino acids. Northern blot and macroarray analyses revealed abundant and ubiquitous expression of p47.