Neurogenic Differentiation 4 (NEUROD4)

Human and mouse NEUROD4 share 88.5% amino acid identity overall and 100% identity within their bHLH regions.NEUROD4 gene contains 2 exons and spans about 10 kb.

Tsuda et al. (1998) stated that mouse Neurod4, which they called Math3, is initially expressed throughout the developing nervous system, then gradually becomes restricted to neural retina. By functional analysis, they identified a proximal region of the Math3 promoter necessary for neuron-specific expression and an upstream region necessary for retinal expression.Lee and Pfaff (2003) showed that Neurod4, which they called NeuroM, and Ngn2 (NEUROG2) actively participated with Isl1 and Lhx3 to specify motor neuron subtype in embryonic chicken spinal cord and in P19 mouse stem cells.