Neurolysin (NLN)

Neurolysin (EC 3.4.24.16) is an enzyme involved in the metabolic inactivation of bioactive peptides.strong expression in human liver, brain, and kidney, moderate expression in heart, skeletal muscle, ovary, spinal cord, fetal liver, and fetal brain, and low expression in pancreas and lung. In specific brain regions examined, amygdala, corpus callosum, and caudate nucleus showed strong expression, with moderate expression in cerebellum, hippocampus, substantia nigra, and thalamus.NLN and thimet oligopeptidase (THOP1) have endopeptidase activity and demonstrated their presence in ovine aortic and human umbilical vein endothelial cells. Both membrane and soluble NLN catalyzed cleavage of bradykinin at the phe5-ser6 bond, although there were other kininases active at this peptide bond.