Neurotrimin (NTM)

Neurotrimin may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.

The deduced 345-amino acid protein contains an N-terminal signal sequence, 3 Ig-like domains, 6 cysteines that likely form intradomain disulfide bonds, and a C-terminal GPI attachment site. Northern blot analysis of several rat tissues detected expression only in brain. In situ hybridization of developing rat brain showed neurotrimin expressed at high levels in several developing projection systems.