Neutrophil Cytosolic Factor 4 (NCF4)

NCF; P40PHOX; SH3PXD4; Neutrophil NADPH Oxidase Factor 4; SH3 and PX domain-containing protein 4
Neutrophil Cytosolic Factor 4 (NCF4)
Neutrophil cytosol factor 4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPA328Ra01Recombinant Neutrophil Cytosolic Factor 4 (NCF4)Customize
  • AntibodyPAA328Ra01Polyclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4)Customize
  • AntibodyMAA328Ra21Monoclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4)Customize
  • Assay KitSEA328RaELISA Kit for Neutrophil Cytosolic Factor 4 (NCF4)Customize
  • Assay KitSCA328RaCLIA Kit for Neutrophil Cytosolic Factor 4 (NCF4)Customize
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