Never In Mitosis Gene A Related Kinase 5 (NEK5)

NEK5is moderately expressed, only 28.6% of the average gene in this release. The sequence of this gene is defined by 32 GenBank accessions from 31 cDNA clones, some from prostate, eye, normal nasopharynx, uterus, embryonic stem cell, retinoic acid andmitogen-treated hes cell line H7, lung, placenta and 11 other tissues.

NEK5 contains 22 different gt-ag introns. Transcription produces 6 different mRNAs, 4 alternatively spliced variants and 2 unspliced forms. There are 3 probable alternative promotors, 4 non overlapping alternative last exons and 3 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of a cassette exon, overlapping exons with different boundaries, alternative splicing or retention of one intron.