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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Nibrin (NBN)
AT-V1; AT-V2; ATV; NBS; NBS1; Nijmegen Breakage Syndrome 1
Nibrin is a protein associated with the repair of double strand breaks(DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to as MRN) double strand DNA break repair complex.This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).Cellular response is performed by damage sensors, effectors of lesion repair and signal transduction. The central role is carried out by ataxia-telangiectasia mutated(ATM) by activating the DSB signaling cascade, phosphorylating downstream substrates such as histone H2AX and NBS1.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPC679Hu01 Recombinant Nibrin (NBN) In Stock
RPC679Hu02 Recombinant Nibrin (NBN) In Stock
Antibodies PAC679Hu01 Polyclonal Antibody to Nibrin (NBN) Customize
PAC679Hu71 Biotin-Linked Antibody to Nibrin (NBN) Customize
MAC679Hu21 Monoclonal Antibody to Nibrin (NBN) Customize
Assay Kits SEC679Hu ELISA Kit for Nibrin (NBN) Customize
SCC679Hu CLIA Kit for Nibrin (NBN) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPC679Mu01 Recombinant Nibrin (NBN) Customize
Antibodies PAC679Mu01 Polyclonal Antibody to Nibrin (NBN) Customize
MAC679Mu21 Monoclonal Antibody to Nibrin (NBN) Customize
Assay Kits SEC679Mu ELISA Kit for Nibrin (NBN) Customize
SCC679Mu CLIA Kit for Nibrin (NBN) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPC679Ra01 Recombinant Nibrin (NBN) Customize
Antibodies PAC679Ra01 Polyclonal Antibody to Nibrin (NBN) Customize
MAC679Ra21 Monoclonal Antibody to Nibrin (NBN) Customize
Assay Kits SEC679Ra ELISA Kit for Nibrin (NBN) Customize
SCC679Ra CLIA Kit for Nibrin (NBN) Customize