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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Niemann Pick Disease Type C1 (NPC1)
NPC1 encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPL138Hu01 Recombinant Niemann Pick Disease Type C1 (NPC1) Customize
Antibodies PAL138Hu01 Polyclonal Antibody to Niemann Pick Disease Type C1 (NPC1) Customize
MAL138Hu21 Monoclonal Antibody to Niemann Pick Disease Type C1 (NPC1) Customize
Assay Kits SEL138Hu ELISA Kit for Niemann Pick Disease Type C1 (NPC1) Customize
SCL138Hu CLIA Kit for Niemann Pick Disease Type C1 (NPC1) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPL138Mu01 Recombinant Niemann Pick Disease Type C1 (NPC1) Customize
Antibodies PAL138Mu01 Polyclonal Antibody to Niemann Pick Disease Type C1 (NPC1) Customize
MAL138Mu21 Monoclonal Antibody to Niemann Pick Disease Type C1 (NPC1) Customize
Assay Kits SEL138Mu ELISA Kit for Niemann Pick Disease Type C1 (NPC1) Customize
SCL138Mu CLIA Kit for Niemann Pick Disease Type C1 (NPC1) Customize