Non Metastatic Cells 7, Protein Expressed In (NME7)

In a review of human Nm23/nucleoside diphosphate kinases (EC 2.7.4.6), Lacombe et al. (2000) stated that the NME7 gene encodes a deduced 376-amino acid protein containing 2 kinase-like domains, each of which lacks 3 residues deemed crucial for catalysis. RT-PCR detected highest NME7 expression in testis, and weaker expression in liver, heart, brain, ovary, small intestine, and spleen.

Mouse Nme7 associated with the centralspindlin complex in transfected HeLa cells. This complex is believed to have a role in spindle assembly and cytokinesis.NME7 gene contains 12 exons spanning over 180 kb.Lacombe et al. (2000) mapped the NME7 gene to chromosome 1q24. NME7 and ATP1B1 lie on opposite strands, with overlapping 3-prime UTRs.