Non SMC Condensin II Complex Subunit H (NCAPH)

Bhat et al. (1996) established that in Drosophila the product of 'barr' (barren) is necessary for sister chromatid separation and modulates topoisomerase II activity. The barr gene is evolutionarily conserved and sequence similarity searches identified a 2.7-kb human homolog.

NCAPH encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization.