Non SMC Element 1 Homolog (NSMCE1)

NSMCE1 Belongs to the NSE1 family.Contains 1 NSE1-type zinc finger.The structural maintenance of chromosomes (SMC) family of proteins play essential roles in genomic stability. SMC heterodimers are required for sister-chromatid cohesion, chromatin condensation, and DNA repair. The SMC heterodimers do not function alone and must associate with essential non-SMC subunits. Nse1 and Nse2 are essential proteins and conserved from yeast to man. Loss of Nse1 and Nse2 function leads to strikingly similar terminal phenotypes to those observed for Smc5–6 inactivation. In addition, cells expressing hypomorphic alleles of Nse1 and Nse2 are, like Smc5–6 mutants, hypersensitive to DNA damage. Epistasis analysis suggests that like Smc5–6, Nse1, and Nse2 function together with Rhp51 in the homologous recombination repair of DNA double strand breaks.